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Director or Sr Director, Clinical Science

San Diego, CA or remote

Erasca is a San Diego based biotechnology company focused on discovering and developing precision medicines for the benefit of patients with cancer. We are advancing multiple programs targeting biological drivers of cancer and are pursuing additional pipeline expansion opportunities through academic and biopharmaceutical collaborations. Our programs, currently focused on innovative discovery research, take novel approaches to shutting down certain oncogene drivers of solid tumor malignancies. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Position Summary: 

The Director or Senior Director of Clinical Science at Erasca will develop, write, and oversee the study protocol for one or more clinical development programs. This individual is responsible for the planning and execution of clinical studies to successfully move the program from IND through to later stage trials. The Director, Clinical Science will work closely with cross-functional teams to develop innovative and efficient solutions to medical and scientific clinical trial issues, and in ensure the successful design, analysis, and completion of clinical trials.  

Note that position will be filled at the Director, Senior Director, or Executive Director level, as appropriate to the background and experience of the successful candidate and the business need. 

Essential Duties and Responsibilities:  

  • Design, oversee, and execute clinical deliverables in support of CDP. May be responsible for multiple studies as the program expands and moves into later-phase trials. 
  • Collaborate on the design, conduct, reporting, and analysis of clinical studies.
  • Key clinical deliverables include document development (INDs, Protocols, IBs, applicable regulatory documents, etc.), medical and scientific input into the development of deliverables required for study activation and study conduct (CRFs, SAP, data listings, etc.), data review process, and other deliverables as needed. 
  • Organize and perform study level and individual subject level analysis of clinical trial data to gain insights and develop strategies for clinical study report (CSR) writing.
  • Attend and contribute, as needed, at meetings with Health Authorities (HAs) related to program; develop responses to HAs and IRBs on clinical/medical questions. 
  • Develop and optimize an effective KOL and investigator network to support the CDP.  
  • Working with other departments, create functional policies and procedures to provide strong and efficient clinical development processes that are scalable and fit for purpose.  
  • Mentor, coach, and potentially directly manage other clinical scientists based on future organizational structure and business need. 
  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations. 

Required Education and Experience: 

  • PhD, PharmD, or other relevant advanced degree in a health science field preferred, equivalent combination of relevant education and experience may also be considered.
  • At least 5 years of biotech or pharmaceutical industry experience as a clinical scientist or in a related clinical development function.  
  • Experience in oncology clinical trials required, early clinical development and phase I protocol writing experience highly preferred.
  • Demonstrated ability to evaluate, interpret, and present complex scientific data.  
  • Deep knowledge of biostatistics, GCP, and regulatory requirements for clinical studies; extensive experience with data analysis and interpretation; understanding of safety and pharmacovigilance principles.
  • Management experience or the desire to develop as a manager, mentor, and leader of staff. 
  • Must be able to work independently and thrive in an entrepreneurial, fast paced, and dynamic work environment. 
  • Highly collaborative team player who fosters open communication and facilitates mutual understanding and cooperation between functions and stakeholders. 
  • Excellent interpersonal, verbal and written communication skills.
  • Intellectually curious with strong critical, strategic, and analytical thinking skills.
  • Passion for science and patients.

Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.

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