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Scientist, Protein Sciences

San Diego, CA

Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Scientist, Protein Sciences

Position Summary: 

Reporting to the Sr Director of Protein Biology, the Scientist, Protein Sciences will play a vital role in the discovery of novel, proprietary clinical candidates to help advance Erasca into a leading drug discovery oncology company. The Scientist, Protein Sciences will provide protein production and assay development support for the characterization of novel pharmaceutically active molecules and be an active member of a cross-functional oncology drug discovery team. 

Essential Duties & Responsibilities: 

  • Contribute to establishing Erasca internal protein production capabilities  
  • Contribute to construct design to enable structural biology and biochemical/biophysical assays  
  • Conduct routine protein expression experiments in E. coli and insect systems 
  • Purify proteins using standard chromatography techniques such as affinity, ion exchange, reverse-phase, and size exclusion chromatography 
  • Maintain a variety of adherent and suspension cell lines for cell-based and proteomics studies 
  • Perform routine biochemical and cell-based assays to characterize lead molecules 
  • Accurately and diligently report experimental findings 
  • Collaborate closely with other functional areas such as structural biology, chemistry, DMPK, and in vivo pharmacology and interpret data related to the projects of interest 
  • Maintain laboratory equipment in good condition and promote common safe work environment practices 
  • Will be required to work approximately 70% in the lab 
  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations 

Desired Experience and Skills:  

  • B.Sc./M. Sc. in Molecular Biology, Cell Biology, Biochemistry, or related disciplines with >3 years of experience in industrial or academic setting required 
  • Proficiency with several analytical techniques, such as LC-MS, DLS, SEC-MALS, protein labeling/conjugation and Tm determination preferred 
  • Experience in design and development of biochemical or cell-based assays 
  • Experience managing protein production at CROs 
  • At least 2 years of drug discovery experience preferred 
  • Excellent organizational skills with a demonstrated ability to devise protocols, document results, and prepare reports, while executing multiple projects concurrently 
  • The successful candidate must have strong interpersonal skills and be highly motivated to work independently in a collaborative, team-oriented setting 
  • Demonstrated ability to achieve high performance goals and meet deadlines in a fast-paced environment   
  • Strong learning orientation, curiosity, and passion for science and patients 

Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.

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