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Sr Scientist, Cancer Biology

San Diego, CA

Erasca is a clinical-stage precision oncology company focused on discovering, developing and commercializing medicines for the benefit of patients with cancer. Our programs take novel approaches to shutting down one of cancer’s most commonly mutated signaling cascades, the RAS/MAPK pathway, which affects approximately 5.5 million lives each year worldwide. The name “Erasca” has an important embedded meaning: it is a contraction of our audacious hope to “erase cancer” that drives our mission and everything that we do on behalf of patients with cancer.

Sr Scientist, Cancer Biology

Position Summary:   

Reporting to the Associate Director, Biology, the Senior Scientist, Biology will be responsible for independently executing technical and laboratory activities that support biology and company objectives. The Sr Scientist will be a key member of a multidisciplinary and fast paced team and will support in vitro biology activities and work closely with in vivo team. This individual will contribute to advancing early discovery and translational programs by studying cancer biology, cell signaling, compound screening, and the mechanism of action of compounds. 

Essential Duties and Responsibilities:  

  • Independently design, plan, execute, and interpret experiments.  
  • In collaboration with cross-functional team, design new experiments, develop cell-based assays, perform in vitro cell-based assays. 
  • Apply scientific expertise in cancer biology to advance drug discovery programs. 
  • Develop and execute cell-based assay cascades to support drug discovery campaigns and MOA studies.  
  • Work effectively with cross-functional teams, providing specialized knowledge and influence to maximize program speed and success. 
  • Contribute expertise in molecular and cellular biology to early drug discovery programs.  
  • Provide ideas and perform research to identify new opportunities to develop and progress novel therapeutic programs. 
  • Effectively communicate strategy, methodology, progress, and challenges to multiple stakeholders and partners. 
  • Regularly present research findings to Erasca colleagues and, as part of a team, to the scientific community through publication in peer-reviewed journals, talks, and posters at scientific meetings. 
  • Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.  

Required Education and Experience: 

  • Ph.D. in molecular, cellular, or cancer biology or related field. 
  • At least 3+ years of post-Ph.D. experience in cancer biology. Industry experience preferred.   
  • Proven track record of successful scientific accomplishments, presentations, and/or peer reviewed publications.  
  • Strong understanding of cancer signaling pathways, protein homeostasis, and regulation of gene expression. 
  • This position requires hands on work at the bench with a recent experience of delivering experimental data proficiency in tissue culture, DNA-, RNA-, and protein-based techniques. 
  • Ability to develop cellular and molecular biology techniques to validate and characterize genetic or small molecule perturbations of targets and downstream pathways.  
  • Proficiency in performing advanced cell-based and molecular biology assays. 
  • Ability to perform routine small molecule compound screening. 
  • Experience in generating stable cell lines and resistance cell generation preferred. 
  • Experience in cell-based drug combination studies also preferred. 
  • Ability to manage external collaborators for effective interaction and data generation a plus.  
  • Effective interpersonal and communication skills and demonstrated productivity working as part of a cross-functional team.  
  • A collaborative team player with a can-do attitude, desire to pitch in where and when needed, and the ability to identify and implement creative solutions to complex technical problems.  
  • Demonstrated ability to achieve high performance goals and meet deadlines in a fast-paced environment.  
  • Strong learning orientation, curiosity, and passion for science and patients.   

Erasca, Inc., is an Equal Opportunity Employer and takes pride in maintaining a diverse and inclusive environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of sex , race, religion, national origin, ancestry, physical or mental disability, protected medical condition, genetic information, marital status, registered domestic partner status, age, sexual orientation, military and veteran status or any other basis protected by federal, state or local law or ordinance or regulation.

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