Research Technician / Research Associate, In vivo Pharmacology



Position Title: Research Technician / Research Associate, In vivo Pharmacology  

Reports To:

Director, Pharmacology

Dept. Name: Pharmacology
Position Summary:
As a member of the biology research team, this individual will focus on in vivo support to translational research efforts and generate nonclinical data packages that support Erasca’s mission of erasing cancer.
Duties & Responsibilities:
Essential duties and responsibilities include the following. Other duties may be assigned.

  • Independently execute in vivo PK/PD/efficacy studies that support nonclinical and clinical stage oncology programs
  • Administer small molecule compounds and biologics to naïve and tumor-bearing rodents (mouse and rat), measure endpoints such as tumor volume and body weight and collect biospecimens
  • Grow and maintain cell lines for tumor implantation
  • Follow study protocol, IACUC protocols, SOP and animal welfare policy in animal studies. Help maintain laboratory and supply inventories
  • Available on weekends and holidays to support animal studies (e.g., animal dosing)
  • Be able to regularly work from Tuesday to Saturday
  • Collect, organize and present scientific/technical data internally and in project team meetings

Perform all duties in keeping with the Company’s core values, policies and all applicable regulations.

Education / Experience:
Education and experience

  • BS in Cancer Biology, Cancer Immunology, and Pharmacology or related field
  • Research Technician or Research Associate with at least 1-2 years’ experience on animal work in oncology field

Technical skills

  • In vivo skills necessary to validate and implement rodent oncology models including
    • Animal study preparation (e.g., ear tag and randomization using computer software)
    • Multiple routes of dosing (e.g., p.o., i.p., i.v. and mini-pump)
    • Measurement of subcutaneous tumor volume by caliper
    • Blood collection via various routes (e.g., tail vein, terminal cardiac and retro orbital)
    • Necropsy and collection of tumor/organs
    • Euthanasia/carcass disposal
    • Animal Husbandry and IACUC experience
  • In vitro skills
    • Cell culture including culture of primary human cancer cells is required
    • Homogenization of tumor samples
  • Have effective troubleshooting, problem-solving and communication skills.
  • Work both independently and collaboratively. Candidates must be flexible and have strong multitasking skills
  • Oncology in vivo experience is highly desired
  • Expertise in Microsoft Office, especially Excel is required. Experience in Prism is desired.
ADA Notations:
While performing the duties of this job, the employee is regularly required to sit, talk, hear and operate a computer.  The employee is occasionally required to stand, walk and use hands and arms and lift and/or move up to 10 pounds. Specific vision abilities required by this job include close vision and ability to adjust focus and see colors.

In this work environment, the employee is occasionally exposed to moving mechanical parts, unpleasant odors and loud noises. Interaction with laboratory equipment, samples, supplies and laboratory personnel may be required whereby appropriate precautions are to be taken per the Company’s Safety and Injury, Illness and Prevention Plans.

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