We are a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for RAS- and MAPK pathway-driven cancers. Molecular alterations in RAS, the most frequently mutated oncogene, and the MAPK pathway, one of the most frequently altered signaling pathways in cancer, account for approximately 5.5 million new cases of cancer worldwide per year.
We believe that to effectively shut down a pathway that signals as promiscuously as RAS/MAPK, a holistic approach must be taken to target not just individual nodes, but multiple nodes and cooperative mechanisms in parallel. Consequently, we are pursuing three therapeutic strategies that may be used in combination to comprehensively, and perhaps synergistically, shut down the RAS/MAPK pathway.
with single agents and combinations intended to clamp these oncogenic drivers (MAPKlampTM).
directly with single agents
to further disrupt RAS/MAPK
To pursue these therapeutic strategies, we are developing what we believe to be the deepest pipeline targeting multiple signaling nodes to shut down the RAS/MAPK pathway. Our approach is modality-agnostic, including small molecules, large molecules, and protein degraders—alone and in combinations across multiple tumor types— to selectively and potently inhibit or degrade critical in-pathway and escape-route signaling nodes of the RAS/MAPK pathway.
At Erasca, we envision a day when the world will no longer suffer from the ravages of cancer. We are passionately committed to creating life-saving medicines—bringing hope, where there was little, that the future can be brighter and cancer free.
Our vision is to one day erase cancer1 in at least 100,000 patients annually as a leading global oncology company.
Our corporate values guide us every step of the way on our journey to erase cancer. They are embodied by our quest for the CURE.
Committed to erasing cancer in patients.
This is why we are here.
United by trust, respect, and integrity.
This is who we are.
Relentlessly focused on team-based execution with agility, creativity, and fun.
This is how we roll.
Exceptional innovation with world-class collaborators.
This is what we do every single day.
At Erasca, while our mission to erase cancer inspires us, we know we can do more to make an even broader contribution to society. To that end, we are pursuing environmental, social, and governance (ESG) initiatives that are aligned with our core mission.
We have established the Erasca Foundation, which has been funded with the donation of 1% of our capital stock. The Erasca Foundation will provide support such as direct research grants, hardship grants, patient advocacy, patient education in underserved populations, and funding for other initiatives to positively impact society.
We intend to make clinical trials of our product candidates more accessible to diverse patient populations and plan to partner with others who are like-minded in this regard.
We intend to provide patients with access to the drugs we develop and commercialize, including through compassionate use programs if our products are demonstrated to be safe and efficacious. We also intend to increase access to life-changing drugs in underserved populations if our products become commercially available.
It extends from our passion and compassion for patients with cancer and their families who motivate us to do our best work, to our social mission that calls us to do more with the resources we’ve been blessed with to be a beacon of hope...Read More